Tetrahydroisoquinoline derivatives

US4667038A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Robin Clark · Palo Alto, US
• Joseph M. Muchowski · Mexico City, MX
• Fang-Ting Chiu · Lansdale, US
• John O. Gardner · Palo Alto, US
• Jacob Berger · Los Altos Hills, US

Key dates

• Filing date: Sep 22, 1986
• Grant date: May 19, 1987
• Expiry date: Sep 22, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 and each independently --H or lower alkoxy; R.sub.3 and R.sub.4 are each independently lower alkyl; and R.sub.5 and R.sub.6 are each --OCH.sub.3, or together form --OCH.sub.2 O-- or --OCH.sub.2 CH.sub.2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.