Process for preparing hydratropic acids and esters thereof, from propiphenones
US4667056A · kind A · utility
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Key dates
| Filing date | May 3, 1985 |
| Grant date | May 19, 1987 |
| Priority date | — |
| Expiry date | May 3, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing hydratropic acids and the esters thereof, of formula Ar--CH(CH.sub.3)--COOR where R=H or lower alkyl and Ar=phenyl possibly substituted. This process consists in reacting on the propiophenones of formula ArCOCH.sub.2 CH.sub.3, a chlorinating or brominating agent, an alcohol R'OH where R'=lower alkyl, an orthoester R.sub.1 --C(OR').sub.3 wherein R.sub.1 =H or lower alkyl, and metal zinc; then possibly hydrolyzing the esters obtained. With this process can be prepared hydratropic acids known for their anti-inflammatory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.