Transdermal drug patches

US4668232A · kind A · utility

Inventors

• G/u/ nter Cordes · Leichlingen, DE
• Michael Wolff · Monheim, DE

Key dates

• Filing date: Dec 18, 1985
• Grant date: May 26, 1987
• Expiry date: Dec 18, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L15/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to transdermal drug patches for the controlled release of drugs to the human skin, comprising PA1 (a) an impermeable backing or covering layer, PA1 (b) a reservoir layer adjacent to, and in close contact with said backing or covering layer, said reservoir layer comprising a polymer matrix composed of a rubber and an adhesive resin material wherein said therapeutically active agent or agents are wholly or partially soluble and which is permeable to said agent or agents, PA1 (c) an adhesive layer adjacent to, and in close contact with, said reservoir layer and permeable to said therapeutically active agent or agents, and PA1 (d) a protective layer covering and adhearing to said adhesive layer and removeable therefrom for the use of said transdermal drug patch, the improvement wherein said drug or drugs in the rubber and adhesive resin material of the reservoir layer are present together with a polymer capable of swelling in water and insoluble in the rubber and adhesive resin material of the reservoir layer, the quantity of said polymer being between 3 and 30% by weight of the rubber and adhesive resin mixture. By the incorporation of this particular water-swell…