Liposome composition for lupus assay
US4668638A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 26, 1983 |
| Grant date | May 26, 1987 |
| Priority date | — |
| Expiry date | Sep 26, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An immunoassay utilizing a novel liposome composition in which there is incorporated a stabilizing or destabilizing component and an antigen. The presence of cognate antibodies in test samples is detected by the alteration of the supramolecular structure of the liposomes resulting in changes in stabilization. Destabilization can be detected, and in certain cases, caused by, the addition of magnesium or calcium ions. Increased stabilization can be detected by the polymerization of bilayer components in response to ultraviolet light. Antibody-antigen interactions at the liposome surface mediate the stabilization/destabilization response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.