Pristinamycin II.sub.B derivatives and compositions containing them

US4668669A · kind A · utility

Assignee

• Rhone-Poulenc Sante · FR

Inventors

• Jean-Claude Barriere · Les Ulis, FR
• Claude Cotrel · Paris, FR
• Jean-Marc Paris · Vaires-sur-Marne, FR

Key dates

• Filing date: Jan 10, 1986
• Grant date: May 26, 1987
• Expiry date: Jan 10, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/27
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Pristinamycin II.sub.B derivatives of formula: ##STR1## in which R denotes a nitrogen-containing 4 to 7-membered heterocyclic ring optionally substituted by alkyl; or alkyl (2 to 4 C) substituted by 1 or 2 phenyl, cycloalkylamino or N-alkyl-N-cycloalkylamino (3 to 6 ring atoms), alkylamino, dialkylamino or dialkylcarbamoyloxy radicals (the dialkylamino moieties of these 2 latter radicals being capable of forming a 4 to 7-membered cyclic ring optionally substituted by alkyl) or substituted by 1 or 2 nitrogen-containing 4 to 7 membered heterocyclic rings, optionally substituted by alkyl, at least one of the above substituents being a nitrogen-containing substituent capable of forming salts and n is 1 or 2, all the alkyls being linear or branched and containing (unless stated otherwise) 1 to 10 carbon atoms, their isomers, their salts and their preparation. These compounds, optionally in combination with known synergistins or synergistins of formula: ##STR2## are useful as antimicrobial agents.