N-substituted isoquinoline derivatives and pharmaceutical compositions containing them
US4668688A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 1984 |
| Grant date | May 26, 1987 |
| Priority date | — |
| Expiry date | Oct 25, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new N-substituted bis(hydroxymethyl)-methyl-isoquinoline derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, PA0 the dotted line is an optional double bond in the 1,2-position, PA0 R.sup.3 is alkyl having from 1 to 6 carbon atoms or aralkyl containing from 1 to 4 carbon atoms in the alkyl moiety, or--if there is a single bond in the 1,2-position--represents a group of the formula ##STR2## in which X is oxygen if PA1 R.sup.4 is alkyl having from 1 to 5 carbon atoms, alkoxy having from 1 to 4 carbon atoms, hydroxyl, phenyl or substituted phenyl; or PA1 X is oxygen or sulfur if PA1 R.sup.4 is an --NH.sub.2, --NH--C.sub.1-4 -alkyl, --NH--C.sub.3-6 -cycloalkyl, --NH-phenyl or --NH--C.sub.1-4 -alkyl-phenyl group; and PA1 R.sup.5 and R.sup.6 independently stand for hydrogen, alkyl having from 1 to 4 carbon atoms or phenyl, with the proviso that at least one of them is other than phenyl, and salts thereof. Processes for the preparation of these compounds and pharmaceutical compositions are also within the scope of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.