Process for the preparation of compounds containing a difluoromethylene or trifluoromethyl group
US4668830A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 17, 1985 |
| Grant date | May 26, 1987 |
| Priority date | — |
| Expiry date | Dec 17, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C41/50
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of compounds containing a difluoromethylene or trifluoromethyl group. A compound containing a carbonyl group, preferbly an acid, acid halide, amide, ketone or any compound containing a perhaloalkylcarbonyl moiety is placed, in anhydrous liquid hydrofluoric acid, in contact with boron trifluoride in a quantity such that the absolute pressure of boron trifluoride in the reaction system is at least one bar for a time sufficient to convert the carbonyl group to a difluormethylene or trifluoromethyl group. The compounds obtained are useful as synthesis intermediates in the pharmaceutical, plant-protection and dye industries, as anesthetics or as heat-transfer and lubricating fluids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.