Hemoglobin combined with a poly(alkylene oxide)
US4670417A · kind A · utility
843Cited by
5References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1986 |
| Grant date | Jun 2, 1987 |
| Priority date | — |
| Expiry date | Feb 21, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure: EQU --CH.sub.2 --O--(CH.sub.2)--CONH--Hb wherein Hb represents said hemoglobin and n represents a positive integer, preferably 1 to 7. The modified hemoglobin is an effective oxygen carrier and can therefore be used as a blood substitute.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.