Process for obtaining complex FVIII/vWF of therapeutical use and resulting products
US4670543A · kind A · utility
7Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1985 |
| Grant date | Jun 2, 1987 |
| Priority date | — |
| Expiry date | Sep 18, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a process for producing FVIII/vWF complexes for therapeutical use possessing both haemophilic A activity and Willebrand activity as well as a high degree of purity, such process substantially comprising the steps of fixing the FVIII/vWF complex in physiological conditions on a particular monoclonal antibody and releasing said complex by means of a suitable elution medium having no effct on the functions of the FVIII/vWF complex but able to dissociate the bonds linking the selected monoclonal anitbody to the FVIII/vWF complex, then collecting the latter in a highly purified form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.