Method for selective methylation of erythromycin a derivatives
US4670549A · kind A · utility
47Cited by
3References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1986 |
| Grant date | Jun 2, 1987 |
| Priority date | — |
| Expiry date | Feb 24, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the selective methylation of the hydroxy group at the 6-position of erythromycin A derivatives which comprises reacting a compound represented by the formula R-X (wherein R is a 2-alkenyl group, a benzyl group or a substituted benzyl group, and X is a halogen atom), reacting the resulting quaternary salt compound with a methylating agent, and then eliminating R groups of the resulting compound to give 6-O-methylerythromycin A 9-oxime, is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.