5-substituted 3-aminoalkyl indoles useful in treatment of migraine
US4672067A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 1984 |
| Grant date | Jun 9, 1987 |
| Priority date | — |
| Expiry date | Jun 28, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents CHO, COR.sub.8, CO.sub.2 R.sub.8, CONR.sub.9 R.sub.10, CSNR.sub.9 R.sub.10 or SO.sub.2 NR.sub.9 R.sub.10, where PA1 R.sub.8 represents alkyl, cycloalkyl, aryl or aralkyl, PA1 R.sub.9 represents hydrogen or alkyl, and PA1 R.sub.10 represents hydrogen or alkyl, cycloalkyl, aryl or aralkyl; PA1 R.sub.2, R.sub.3, R.sub.4, R.sub.6 and R.sub.7 each independently represents hydrogen or C.sub.1-3 alkyl; PA1 R.sub.5 represents hydrogen, or alkyl, cycloalkyl, alkenyl or aralkyl, or PA1 R.sub.4 and R.sub.5 together form an aralkylidene group or R.sub.4 and R.sub.5 together with the attached nitrogen atom form a saturated monocyclic 5- to 7-membered ring; and PA1 Alk represents C.sub.2-3 alkylene chain optionally substituted by not more than two C.sub.1-3 alkyl groups; and physiologically acceptable salts and solvates thereof. The compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner using pharmaceutically acceptable carriers or excipients. The compounds may be prepared by, for example, reaction of an aminoalkyl indole with an acid of f…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.