Antianaphylactic and antibronchospastic piperazinyl-(N-substituted phenyl)carboxamides, compositions and use

US4675319A · kind A · utility

Assignee

• Recordati S.A. Chemical and Pharmaceutical Company · CH

Inventors

• Dante Nardi · Milano, IT
• Amedeo Leonardi · Milano, IT
• Gianni Motta · Barlassina, IT
• Pietro Cazzulani · Milano, IT

Key dates

• Filing date: Jun 9, 1986
• Grant date: Jun 23, 1987
• Expiry date: Jun 9, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D339/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel piperazine derivatives having the general formula: ##STR1## wherein R is hydrogen or lower alkyl, A is straight or branched chain lower alkyl, and R.sub.1 and R.sub.2 are each hydrogen, amino, alkylamino, dialkylamino, mono- or di(hydroxyalkyl)amino, morpholino, pyrrolidino, piperidino, N-alkylpiperazino, 1,3-dithiolan-2-ylidenamino, or N-alkylureido, with the proviso that at least one of R.sub.1 and R.sub.2 is other than hydrogen, or the isomeric mixtures, individual enantiomers or pharmaceutically acceptable acid addition salts thereof, are therapeutically useful antianaphylactic and antibronchospastic agents.