3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity
US4675403A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 16, 1985 |
| Grant date | Jun 23, 1987 |
| Priority date | — |
| Expiry date | Oct 16, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula ##STR1## wherein Y represents ##STR2## R and R.sup.1 are each, independently, hydrogen, lower alkyl, phenyl or naphthyl, with that proviso that when R and R.sup.1 are both phenyl, R.sup.2 is other than phenyl; PA1 Z is ##STR3## R.sup.2 is 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyridinyl, halopyridin-2-yl, cyanopyridin-2-yl, phenyl or phenyl substituted with lower alkyl, halo or trifluoromethyl; PA1 R.sup.3 is phenyl or phenyl substituted with halo or trifluoromethyl; PA1 m is 2-7; PA1 n is 2-5; and and the pharmaceutically acceptable salts thereof and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.