8-pyridazinylcarbamoyl ergolines
US4675404A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 1986 |
| Grant date | Jun 23, 1987 |
| Priority date | — |
| Expiry date | Jul 14, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D457/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Ergoline derivatives of formula: ##STR1## wherein n=0,1,2; R.sub.1 =H, CH.sub.3 ; R.sub.2 =H, CH.sub.3, halogen; R.sub.3 =H, OCH.sub.3 ; R.sub.4 =hydrocarbon group and R.sub.5 is a residue of general formula II, III, IV, V, VI, VII: ##STR2## wherein R.sub.6 =H, Cl, OCH.sub.3, NR.sub.11 R.sub.12, wherein R.sub.11 and R.sub.12 =H, lower alkyl; phenyl or are bonded together to form a heterocyclic ring, R.sub.7, R.sub.8 and R.sub.9 and R.sub.10 =H or C.sub.1 -C.sub.3 alkyl, with the proviso that if R.sub.5 is of formula II and R.sub.2 =R.sub.7 =R.sub.8 =H, then R.sub.4 is not methyl or n is not 0. Pharmaceutically acceptable acid addition salts are also provided. A method for their preparation is also provided. The compounds have anti-depressive, anti-hypertensive and antiprolactin activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.