4-oxo-pyrido[2,3-d]pyrimidinone derivatives

US4677108A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Jurgen Kleinschroth · Denzlingen, DE
• Gerhard Satzinger · Denzlingen, DE
• Karl Mannhardt · Hornberg, DE
• Johannes Hartenstein · Kirchzarten, DE
• Hartmut Osswald · Völklingen, DE
• Gunter Weinheimer · Denzlingen, DE
• Edgar Fritschi · Giengen an der Brenz, DE

Key dates

• Filing date: Oct 16, 1985
• Grant date: Jun 30, 1987
• Expiry date: Oct 16, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-Oxo-pyrido[2,3-d]pyrimidine derivatives are herein described as well as processes for their preparation. These compounds possess valuable pharmacological properties. As calcium antagonists they exert vasospasmolytic, vasodilatory, and antihypertensive activities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.