1-(6-(2'-substiuted-5', 6', 7', 8'-tetrahydro-4',-oxo-quinazolino))-3-4-dihydro-6,7-disubstituted-isoqui noline derivatives and pharmaceutical compostions containing them
US4677109A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 10, 1985 |
| Grant date | Jun 30, 1987 |
| Priority date | — |
| Expiry date | Apr 10, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoquinol ine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms, PA1 R.sup.3 is alky having from 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an optionally substiutted heterocyclic group, and acid addition and quaternary salts thereof. Compounds of the formula (I) are pharmaceutically active, in particular show spasmolytic, analgesic, antipyretic activity and have a protecting effect in acute alcoholic intoxication.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.