Sulfur-containing 6-ketoprostaglandins

US4680288A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Klaus Irmscher
• Hans-Eckart Radunz · Darmstadt, DE
• Ernst-Friedrich Schulze · Darmstadt, DE
• Bernhard Riefling · Darmstadt, DE

Key dates

• Filing date: Jan 18, 1985
• Grant date: Jul 14, 1987
• Expiry date: Jan 18, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Sulfur-containing 6-ketoprostaglandins of the formula I ##STR1## in which D is a bond, alkylene having 1-3 C atoms, cis-alkenylene having 2-5 C atoms or alkinylene having 2-5 C atoms, PA1 R.sup.1 is H, alkyl having 1-4 C atoms, aryl having 6-12 C atoms or --C.sub.6 H.sub.4 NHCOC.sub.6 H.sub.5, PA1 R.sup.2 is alkyl having 1-7 C atoms, alkyl having 1-7 C atoms which is substituted by halogen, cycloalkyl having 5-6 C atoms, cycloalkyl having 5-6 C atoms which is substituted by alkyl having 1-4 C atoms, phenyl, phenyl which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH.sub.3 or CF.sub.3, pyridyl, naphthyl, thienyl or, if D is alkylene having 1-3 C atoms, also is alkoxy having 1-4 C atoms, alkylthio having 1-4 C atoms, phenoxy or phenoxy which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH.sub.3 or CF.sub.3, PA1 R.sup.3 and R.sup.4 each are H, alkyl having 1-7 C atoms, tetrahydro-2-pyranyl, trialkylsilyl having a total of 3-12 C atoms, aryldialkylsilyl having a total of 8-18 C atoms, alkoxymethyl having 2-5 C atoms, aryloxymethyl having 7-11 C atoms or acyl having 1-10 C atoms, and PA1 R.sup.5 is H or alkyl having 1-3 C atoms, and PA1 .... indicates that…