Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4680292A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1984 |
| Grant date | Jul 14, 1987 |
| Priority date | — |
| Expiry date | Dec 13, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Carbapenems and 1-methylcarbapenems having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently H, CH.sub.3, CH.sub.3 CH.sub.2 --, (CH.sub.3).sub.2 CH--, HOCH.sub.2, CH.sub.3 CH(OH)--, (CH.sub.3).sub.2 C(OH)--, FCH.sub.2 --, F.sub.2 CH, F.sub.3 C--, CH.sub.3 CH(F)--, CH.sub.3 CF.sub.2 --, or (CH.sub.3).sub.2 C(F)--; PA0 R.sup.3 is H-- or CH.sub.3 ; PA0 L is PA1 a bridging group comprising substituted or unsubstituted C.sub.1 -C.sub.4 straight, C.sub.2 -C.sub.6 branched or C.sub.3 -C.sub.7 cycloalkyl groups wherein the substituents are selected from C.sub.1 -C.sub.6 alkyl, O--C.sub.1 -C.sub.6 alkyl, S--C.sub.1 -C.sub.6 alkyl, CF.sub.3, N(C.sub.1 -C.sub.6 alkyl).sub.2 ; PA1 N.sup.+ is a quaternary, monocyclic or bicyclic substituted or unsubstituted, heteroaryl group containing (a) when monocyclic, up to 3 heteroatoms and up to 6 total ring atoms, or (b) when bicyclic, up to 5 heteroatoms and 9-10 ring atoms, which is optionally substituted with one or more groups; their preparation and antibiotic use are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.