Thioformamide derivatives and use in inhibiting gastric secretion
US4680303A · kind A · utility
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3Claims
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Key dates
| Filing date | Nov 18, 1985 |
| Grant date | Jul 14, 1987 |
| Priority date | — |
| Expiry date | Nov 18, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Thioformamide derivatives of formula: ##STR1## in which R is hydrogen or alkyl (1 to 4 C), R.sub.1 is alkyl (1 to 4 C), and X denotes sulphur or oxygen and Y is sulphur, oxygen, methylene radical, or, when X is oxygen, a valency bond, are inhibitors of gastric secretion and therefore useful in the treatment of gastric ulcers. They may be made by reaction of an amine R--NH.sub.2 with a corresponding thioester or, when R is alkyl, by reaction of an alkyl isothiocyanate with the product of reacting a base with a compound of formula: ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.