Temperature stable crystalline di(1-methyl-2-pyrralidinone) and di(N-formylpyrrolidine) adducts of cephalosporin derivatives
US4680389A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 10, 1986 |
| Grant date | Jul 14, 1987 |
| Priority date | — |
| Expiry date | Jan 10, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/545
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Crystalline adducts of 7-[(Z)-2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido-3-[(1-methyl-1-pyrr olidinium)methyl]-3-cephem-4-carboxylate selected from the group consisting of the di(1-methyl-2-pyrrolidinone) adduct and the di(N-formyl pyrrolidine) adduct and salt complexes thereof have been found to be stable at even high temperatures. The crystalline adducts are prepared by forming an admixture of adducting agents, zwitterions and seed adduct crystals and inducing crystallization followed by isolating the crystals. A process for preparing adduct salt complexes is also disclosed. Crystalline zwitterion can be formed by slurrying the adducts in a solvent which removes the adducting agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.