Apovincaminol derivative
US4680397A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 25, 1985 |
| Grant date | Jul 14, 1987 |
| Priority date | — |
| Expiry date | Apr 25, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new apovincaminol derivatives of the formula /I/ ##STR1## wherein R.sub.1 is hydrogen, nitro or halogen, PA1 R.sub.2 is a substituted or unsubstituted alkyl or phenyl group, PA1 R.sub.3 and R.sub.4 together form a valency bond or each independently represents hydrogen, hydroxyl or an --OR.sub.5 group, in which PA1 R.sub.5 is substituted or unsubstituted alkanoyl or benzoyl group, with the proviso that if R.sub.2 stands for a 3,4,5-trimethoxyphenyl group and R.sub.1 is hydrogen, R.sub.3 and R.sub.4 together do not form a valency bond, or if R.sub.2 is a 3,4,5-trimethoxyphenyl group and R.sub.3 and R.sub.4 both are hydrogen, R.sub.1 is other than hydrogen, nitro or bromine, and acid addition salts thereof. The compounds may be used in the therapy of various skin diseases accompanied by a pathological cell proliferation, preferably psoriasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.