Dihydro-2,6-dimethyl pyridines, formulations and method of use for treating angina pectoris, high blood pressure or disturbances of cerebral or peripheral blood flow

US4681891A · kind A · utility

Assignee

• Cassella Aktiengesellschaft · DE

Inventors

• Karl Schonafinger · Alzenau, DE
• Helmut Bohn · Schöneck, DE
• Piero Martorana · Bad Homburg vor der Höhe, DE
• Rolf-Eberhard Nitz · Frankfurt am Main, DE

Key dates

• Filing date: Nov 12, 1985
• Grant date: Jul 21, 1987
• Expiry date: Nov 12, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1,4-dihydropyridines of the formula I ##STR1## wherein R.sup.1 denotes optionally substituted phenyl, pyridyl or thienyl, R.sup.2 denotes optionally substituted oxadiazolyl, thiadiazolyl or thiazolyl and R.sup.3 denotes hydrogen or --COOH, their preparation by a modified Hantzsch synthesis and their use as a calcium-agonist in pharmacy.