2,6-Dimethyl-3N,5-disubstituted-4-(substituted phenyl)3,4-dihydropyrimidine compounds and a method for treating disorders of cardiocircular system
US4683234A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1985 |
| Grant date | Jul 28, 1987 |
| Priority date | — |
| Expiry date | Mar 6, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-substituted 3,4-dihydropyrimidine derivatives of the formula: ##STR1## wherein X.sup.1, X.sup.2 and X.sup.3 are the same or different and are hydrogen, nitro, halogen, cyano, trifluoromethyl, methylthio or lower alkoxy; PA0 R.sup.1 is (C.sub.1 -C.sub.13) straight or branched alkoxy, (C.sub.4 -C.sub.12) straight or branched alkenyloxy, (C.sub.5 -C.sub.8) straight or branched alkynyloxy, (C.sub.1 -C.sub.4) straight or branched alkyl, (C.sub.3 -C.sub.6) cycloalkyl, PA0 --O--(CH.sub.2).sub.n --A wherein n is 1, 2 or 3, A is cyclopropyl, cyclobutyl, cyclopentyl, or (C.sub.1 -C.sub.3) haloalkyl, PA0 --O--(CH.sub.2).sub.m --O--B wherein m is 1, 2, 3 or 4, B is (C.sub.1 -C.sub.3) alkyl, or PA0 --O--(CH.sub.2).sub.l --D wherein l is an integer from zero to 8, D is phenyl or substituted phenyl; PA0 R.sup.2 is (C.sub.1 -C.sub.12) straight or branched alkyl, (C.sub.4 -C.sub.7) straight or branched alkenyl, --(CH.sub.2).sub.p --E wherein p is 1, 2 or 4, E is cyclopropyl, cyclobutyl or cyclopentyl, ##STR2## wherein q is 2, 3 or 4, G and J are the same or different and are phenyl, methyl, ethyl, isopropyl, benzyl, phenethyl, methoxycarbonyl or ethoxycarbonyl, or --(CH.sub.2).sub.r --O--L wherei…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.