Anti-fungal homopropargylamines, compositions, and method of use therefor

US4684661A · kind A · utility

Assignee

• Sandoz AG · CH

Inventor

• Anton Stuetz · Mödling, AT

Key dates

• Filing date: Nov 20, 1985
• Grant date: Aug 4, 1987
• Expiry date: Nov 20, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P17/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel homopropargylamines of formula I ##STR1## wherein n is 2 or 3, PA1 R.sub.1 is a group of formula IIa, IIb or IIc ##STR2## in which R.sub.6 and R.sub.7 independently are H, halogen, CF.sub.3, lower alkyl or lower alkoxy, PA2 s is a number of 3 to 5, PA2 X is O, S, OCH.sub.2, SCH.sub.2, CH.sub.2 or NR.sub.8, and PA2 R.sub.8 is H or lower alkyl, PA1 R.sub.2 is H or lower alkyl, either PA1 R.sub.3 and R.sub.4, independently, are H or lower alkyl, or PA1 R.sub.3 and R.sub.4 together are (CH.sub.2).sub.u, in which u is a number of 3 to 5, and PA1 R.sub.5 is H, alkenyl or is a group selected from alkyl, trialkylsilyl, dialkylphenylsilyl, phenyl, phenylalkyl and cycloalkyl, in which alkyl, phenyl and cycloalkyl groups or moieties are unsubstituted or substituted by OH, lower alkyl, lower alkoxy, phenyl or halogen, in free base form or acid addition salt form thereof, their preparation, their chemotherapeutical and agricultural use and to compositions comprising such novel compounds and suitable for such use.