Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
US4686098A · kind A · utility
73Cited by
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3Claims
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Key dates
| Filing date | May 14, 1984 |
| Grant date | Aug 11, 1987 |
| Priority date | — |
| Expiry date | May 14, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovine growth hormone. The transformed mouse cells were encapsulated in hollow fibers and implanted into animals, thereby producing circulating bovine growth hormone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.