Beta-d-galactose derivatives and their use

US4686193A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventor

• Cenek Kolar · Marburg, DE

Key dates

• Filing date: May 27, 1983
• Grant date: Aug 11, 1987
• Expiry date: May 27, 2003

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/80
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

New compounds of the general formula I ##STR1## in which R.sup.1 and R.sup.2 each denote a hydrogen atom or an acyl or benzyl protective group, PA1 R.sup.1 and R.sup.2 together denote an alkylidene or benzylidene protective group, PA1 R.sup.4 denotes a hydrogen atom, an acyl or benzyl protective group or a 2,3,4-tri-O-benzyl-.alpha.-L-fucopyranosyl or .alpha.-L-fucopyranosyl radical, PA1 R.sup.5 denotes H, OH, NH.sub.2, NHNH.sub.2, N.sub.3, O-alkyl, O-aryl, NH--(CH.sub.2).sub.m NH.sub.2, where m=2-5, lysine, polylysine or a carrier, PA1 n denotes a number from 1 to 10 and PA1 R.sup.3 denotes a hydrogen atom, an acyl or benzyl protective group or an .alpha.-D-glycopyranosyl radical of the general formula II ##STR2## in which R.sup.6 denotes a hydrogen atom or an acyl or benzyl protective group, PA1 R.sup.7 denotes a hydrogen atom or halogen and PA1 R.sup.8 denotes a hydrogen atom, an acyloxy or benzyloxy group or an azido, amino, acetamido or hydroxyl group, a process for their preparation and their use, when bonded to a carrier, as synthetic antigens, glycolipids or immuno-adsorbents, are described.