Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates and method of use

US4686208A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Oswald Lockhoff · Cologne, DE
• Bernd-Wieland Kruger · Wittlich, DE
• Peter Stadler · Haan, DE
• Arnold Paessens · Haan, DE
• Gert Streissle · Wuppertal, DE
• Peter Taylor · San Marino, US
• Hans-Joachim Zeiler · Velbert, DE
• Karl G. Metzger · Wuppertal, DE

Key dates

• Filing date: Nov 21, 1984
• Grant date: Aug 11, 1987
• Expiry date: Nov 21, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## in which R.sup.1 represents an optionally substituted, straight-chain or branched, saturated, monounsaturated or polyunsaturated alkyl radical, an optionally substituted, saturated or one- or polyunsaturated cycloalkyl radical or an optionally substituted aryl radical or aralkyl radical, PA1 X represents CH.sub.2, O, S, NH or N-alkyl with up to 20 C atoms, PA1 R.sup.2 has the meaning of R.sup.1, and can represent hydrogen if X denotes CH.sub.2, the radicals R.sup.3 independently of one another represent hydrogen, an acyl radical or alkyl radical with in each case up to 20 C atoms, a silyl radical and/or a phosphoric acid or phosphoric acid ester radical and PA1 R.sup.4 denotes hydrogen, methyl or --CH.sub.2 --OR.sup.3, with the proviso that one of the radicals R.sup.3 always represents a phosphoric acid or phosphoric acid ester radical, which stimulate a patient's immune system and are thereby effective in combating viral disease and bacterial infection.