Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
US4686213A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 15, 1986 |
| Grant date | Aug 11, 1987 |
| Priority date | — |
| Expiry date | Aug 15, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed. Included are compounds of the formula ##STR1## wherein R.sup.1 is --H or lower alkyl containing 1 to 3 carbon atoms; R.sup.2 is --NH.sub.2, --NHCHO, --NHCONH.sub.2, --OCH.sub.3, oxo; R.sup.3 is --H or lower alkyl containing 1 to 3 carbon atoms and the pharmaceutically acceptable salts thereof when R.sup.1 is --H.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.