Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines
US4686217A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1984 |
| Grant date | Aug 11, 1987 |
| Priority date | — |
| Expiry date | Apr 17, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are described compounds of formula I, ##STR1## in which R.sub.1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted, PA1 --COOR.sub.2 and --COOR.sub.3 are various ester groups, PA1 one of R.sub.7 and R.sub.8 represents alkyl Cl to 6 and the other represents --CONR.sub.10 R.sub.11 ; --CSNH.sub.2 ; --C(.dbd.NH)SR.sub.9 ; --S(O).sub.m R.sub.9 ; phenyl optionally substituted by one or more of alkyl Cl to 6, halogen, alkoxy Cl to 6 or nitro; alkyl Cl to 6 substituted by halogen; or furanyl; PA1 m is 0 or 1 PA1 R.sub.9 is alkyl Cl to 6, and PA1 R.sub.10 and R.sub.11 each independently represent hydrogen or alkyl Cl to 6, or together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring. There are also described processes for making the compounds, and pharmaceutical, e.g. calcium antagonist, formulations containing them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.