Method of inactivating reproducible pathogens

US4687664A · kind A · utility

Assignee

• Immuno Aktiengesellschaft fur chemisch-medizinische Produkte · AT

Inventors

• Anton Philapitsch · Staprijk, AT
• Gunter Wober · Oberwaltersdorf, AT
• Johann Eibl · Wien, AT
• Otto Schwarz · Waldshut-Tiengen, DE

Key dates

• Filing date: Apr 30, 1984
• Grant date: Aug 18, 1987
• Expiry date: Apr 30, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is described a method of inactivating reproducible pathogens in preparations containing plasmatic enzymes and proenzymes, activated or non-activated coagulation factors, such as Factors II, V, VII, VIII, IX, X, XIII, "FEIBA", prothrombin complex preparations, plasmatic inhibitors, immunoglobulins or other blood products, such as fibronectin and fibrinogen. In order to break and overcome the protective effect of proteins on pathogens by simultaneously preserving the biological activity and the molecular integrity of the proteins, the preparation is adjusted to a salt concentration of more than 0.5 molar by the addition of ammonium sulfate and is thermally treated, whereupon the ammonium sulfate is removed from the preparation.