Des-proline-N-methylarginine vasopressins
US4687758A · kind A · utility
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8Claims
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Key dates
| Filing date | Nov 19, 1985 |
| Grant date | Aug 18, 1987 |
| Priority date | — |
| Expiry date | Nov 19, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/15
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides having vasopressin antagonist activity are prepared by a peptide synthesizer to insert a N-methylarginine at the 7-position of the structure. An example of this series of compounds is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-7-desproline-8-N-methylarginine-9-de sglycine]-vasopressin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.