Tripeptide and tetrapeptide esters which inhibit gastric secretion, process for their preparation and pharmaceutical compositions in which they are present
US4687759A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 16, 1985 |
| Grant date | Aug 18, 1987 |
| Priority date | — |
| Expiry date | Dec 16, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to the peptides of the formula: ##STR1## in which: R represents hydrogen or a protecting group for the terminal amine group, such as t-butoxycarbonyl (Boc), benzyloxycarbonyl (Z) or lower alkanoyl; PA0 X.sub.1 represents either beta-Ala or a direct bond between R and the terminal amine group of the amino acid TRP; PA0 TRP denotes either the L isomer or the D isomer of tryptophan; PA0 X.sub.2 represents L-leucine, L-methionine or L-norleucine; and PA0 Y denotes hydrogen, a halogen atom (preferably fluorine or chlorine), a trifluoromethyl group, a cyano group or a nitro group. These peptides inhibit gastric secretion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.