Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6
US4687844A · kind A · utility
8Cited by
1References
7Claims
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Key dates
| Filing date | Apr 11, 1986 |
| Grant date | Aug 18, 1987 |
| Priority date | — |
| Expiry date | Apr 11, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D407/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the direct preparation of N,N-di-substituted derivatives of 4,13-diaza-18-crown-6 in which the substituents on both nitrogen atoms are identical and derive originally from an amine, by reacting a 1,8-diiodo-3,6-dioxooctane or derivatives thereof in which the substituents are located on positions 1, 2, 4, 5, 7 or 8 or combinations thereof, with a molar equivalent of a primary amine in the presence of a base and solvent.
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