Therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives
US4690931A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 1985 |
| Grant date | Sep 1, 1987 |
| Priority date | — |
| Expiry date | Sep 9, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R.sub.2 is hydroxyl or methoxy in the 4-position and R.sub.3 is hydrogen, R.sub.1 may also represent hydroxymethyl carbamoyl or alkoxycarbonyl, PA0 R.sub.2 is hydrogen, halogen, alkyl, hydroxyl, or alkoxy, PA0 R.sub.3 is hydrogen or alkyl, PA0 R.sub.4 is alkyl (in which case the compounds are (.+-.)-erythro) or when R.sub.3 represents hydrogen, R.sub.4 may also be hydrogen, and R.sub.5 is hydrogen, halogen, alkyl, alkoxy, or three methoxy groups in the 3-, 4- and 5-positions and pharmaceutically acceptable acid addition salts thereof, with the exclusion of compounds wherein: PA0 (a) one of R.sub.1 and R.sub.2 is in the 4-position and is hydroxyl, alkoxy or benzyloxy, the other is in the 3-position and is hydrogen, hydroxyl, alkoxy or benzyloxy, and R.sub.3 and R.sub.5 are hydrogen and wherein: PA0 (b) R.sub.1 is in the 4-position and is halogen, R.sub.4 is methyl and R.sub.2, R.sub.3 and R.sub.5 are hydrogen, are useful as medicaments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.