New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them
US4691024A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 1986 |
| Grant date | Sep 1, 1987 |
| Priority date | — |
| Expiry date | Oct 3, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides new mitomycin derivatives of general formula (I) ##STR1## [wherein Y and Z, which may be the same or different, each represents a hydrogen atom or a methyl group; PA1 represents .alpha. or .beta. bonding and X represents a group of formula (II) ##STR2## (wherein R.sub.1 to R.sub.5 are each selected from hydrogen, halogen, hydroxyl, nitro, amino, lower alkyl, lower alkoxy, lower alkylamino or lower alkanoylamino); PA1 or an S-yl group of an amino acid having a thiol group, the carboxyl group optionally being protected e.g. in the form of a lower alkyl ester group and the amino group optionally being protected e.g. in the form of a lower alkanoylamino group; PA1 or an S-yl group of a di- or tripeptide containing an amino acid residue with a thiol group, the carboxyl group optionally being protected e.g. in the form of a lower alkyl ester and the amino group optionally being protected e.g. in the form of a lower alkanoylamino group]; and salts thereof. Such mitomycin derivatives have improved anti-bacterial and anti-tumor activities and low toxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.