2-phenylethylamine derivatives

US4692465A · kind A · utility

Assignee

• Beecham Group plc · GB

Inventors

• Richard M. Hindley · Reigate, GB
• John Berge · Kongsberg, NO

Key dates

• Filing date: Aug 15, 1984
• Grant date: Sep 8, 1987
• Expiry date: Aug 15, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R.sup.1 and/or R.sup.2 wherein R.sup.1 is halogen, trifluoromethyl or hydroxy and R.sup.2 is halogen; PA1 R.sup.3 is hydrogen or methyl; PA1 X is --O(CH.sub.2).sub.a CO.sub.2 H, --O(CH.sub.2)bM or --CO.sub.2 H in which PA1 a is an integer from 1 to 6, PA1 b is an integer from 2 to 7, PA1 M is hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy, or --NR.sup.4 R.sup.5 in which R.sup.4 and R.sup.5 are each hydrogen or C.sub.1-6 alkyl or together form a five or six membered heterocyclic ring; PA1 Y is C.sub.2-6 straight or branched alkylene, with at least two carbon atoms between the --O-- and --OH; PA1 and n is 1 or 2, having anti-obesity and/or anti-hyperglycaemic activity, processes for their preparation and their pharmaceutical use.