C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-.alpha.-(substituted-oximino)acety l]cephalosporin derivatives

US4692517A · kind A · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• Jerauld S. Skotnicki · Allentown, US
• Thomas J. Commons · Wayne, US

Key dates

• Filing date: Mar 20, 1986
• Grant date: Sep 8, 1987
• Expiry date: Mar 20, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D501/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are disclosed novel antibacterial compounds having the formula ##STR1## wherein R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cyclo lower alkyl, aryl of 6-12 carbon atoms, all the said foregoing groups being optionally substituted with carboxy, lower alkoxycarbonyl, phenoxycarbonyl, amino, mono- or di-lower alkyl substituted amino, hydroxy, lower alkoxy, phenoxy, carbamoyl, lower alkyl carbonyl, benzoyl, cyano, nitro, formamido, lower alkanoylamino or benzamido; PA1 R.sup.1 is hydrogen, lower alkyl or an alkali metal cation; PA1 A is lower alkoxy, lower alkenoxy, lower alkynoxy, aryloxy of 6-12 carbon atoms, di-lower alkyl substituted amino, di-lower alkenyl substituted amino, di-lower alkynyl substituted amino, di-aryl of 6-12 carbon atoms substituted amino, lower alkyl, lower alkenyl, lower alkynyl, aryl of 6-12 carbon atoms.