Patent · US Expired

2-amino-3,5-di-(halomethyl)-pyrazines and their preparation

US4692527A · kind A · utility

1Cited by

1References

3Claims

0Family size

Assignee

BASF SE

Inventors

Hartmut Leininger · Neustadt, DE
Wolfgang Littmann · Mannheim, DE
Joachim Paust · Schifferstadt, DE
Walter Trautmann · Marl, DE

Key dates

Filing date	Sep 16, 1985
Grant date	Sep 8, 1987
Priority date	—
Expiry date	Sep 16, 2005

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

2-Amino-3,5-di-(halomethyl)-pyrazines of the general formula I ##STR1## where X is either chlorine or bromine, m and n may each be 0, 1, 2 or 3 and R.sup.1 and R.sup.2 are each hydrogen or a protective group or may furthermore be bonded to one another, in particular those compounds of the formula I in which m is 1 and n is 2 and/or R.sup.1 and R.sup.2 together form a phthaloyl radical, are useful intermediates for the pteridine building block of folic acid or folic acid analogs. They are obtained by a method in which a 2-amino-3,5-dimethylpyrazine of the general formula II ##STR2## is treated with a chlorinating or brominating agent and, where R.sup.1 and/or R.sup.2 are protective groups, these are, if desired, eliminated when the chlorination or bromination is complete.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.