Human monoclonal antibodies from lymphocytes of patients with malignant melanoma

US4693966A · kind A · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• Alan Houghton · New York, US
• Hannah Brooks · Montville, US
• Richard J. Cote · Los Angeles, US
• Herbert F. Oettgen · New Canaan, US
• Lloyd J. Old · New York, US

Key dates

• Filing date: Mar 11, 1983
• Grant date: Sep 15, 1987
• Expiry date: Mar 11, 2003

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/865
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Human monoclonal antibodies which specifically bind to antigens found on cell surfaces of renal, lung, and breast cancer cells, intracellular cytoskeletal antigens, nuclear antigens, and cytoplasmic reticular antigens are disclosed. The antibodies are the product of hybridoma cell lines, where the immortal cell line may be, e.g., a human cell line, or a murine cell line.