Preparation of inactivated viral vaccines
US4693981A · kind A · utility
90Cited by
5References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 7, 1985 |
| Grant date | Sep 15, 1987 |
| Priority date | — |
| Expiry date | Oct 7, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20263
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.