Fatty acid salts of betaxolol useful in the treatment of glaucoma
US4694022A · kind A · utility
3Cited by
4References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 24, 1986 |
| Grant date | Sep 15, 1987 |
| Priority date | — |
| Expiry date | Dec 24, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C53/126
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fatty acid salts of betaxolol, a cardioselective beta-blocker, and ophthalmic compositions containing these salts are described. These new salts have an aqueous solubility significantly less than that of betaxolol hydrochloride. This relatively poor aqueous solubility enables the salts to be slowly released from a suitable ophthalmic vehicle when placed in the aqueous environment of the eye. The salts also exhibit a significantly lower incidence of ocular irritation, as compared to ophthalmic solutions containing betaxolol hydrochloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.