Enzymatic detection of bacterial capsular polysaccharide antigens
US4695541A · kind A · utility
9Cited by
2References
16Claims
0Family size
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Key dates
| Filing date | Jan 31, 1985 |
| Grant date | Sep 22, 1987 |
| Priority date | — |
| Expiry date | Jan 31, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially pure enzyme which hydrolyzes a polymer containing an .alpha. 2,8-linked N-acetyl neuraminic acid is obtained from K1-specific bateriophages and used for assays of bacterial polysaccharides in samples such as cerebrospinal fluid for testing for various disorders such as bacterial meningitis, septicemia, bacteremia, and the like. The enzyme may also be used therapeutically in treating such disorders by attacking cells which have an increased level of a polymer containing an .alpha. 2,8-linked N-acetyl neuraminic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.