3-aminocarbonylmethoxy-5-phenylpyrazole compounds, antiarrythmic compositions containing them, and intermediates in their preparation

US4695566A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Henning Heinemann · Hannover, DE
• Wolfgang Kehrbach · Hannover, DE
• Uwe Schoen · Burgdorf, DE
• Gerd Buschmann · Velbert, DE
• Ulrich Kuhl · Gehrden, DE

Key dates

• Filing date: Jul 2, 1985
• Grant date: Sep 22, 1987
• Expiry date: Jul 2, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-(aminoalkylaminocarbonylmethoxy)-5-phenylpyrazole compounds corresponding to the formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 and R.sub.9 may be hydrogen or lower alkyl groups, or R.sub.5 with R.sub.6 and/or R.sub.8 with R.sub.9 may also form specified cyclic groups, R.sub.3 and R.sub.4 may be hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, nitro, hydroxy or alkylene dioxy, and Z represents an alkylene chain or the 2-hydroxypropylene chain. The compounds possess pharmacological, in particular antiarrhythmic, properties.