Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4695624A · kind A · utility
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20Claims
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Key dates
| Filing date | Apr 4, 1985 |
| Grant date | Sep 22, 1987 |
| Priority date | — |
| Expiry date | Apr 4, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/831
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.