Process for the preparation of 16,17 acetals of pregnane derivatives
US4695625A · kind A · utility
31Cited by
2References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 30, 1985 |
| Grant date | Sep 22, 1987 |
| Priority date | — |
| Expiry date | May 30, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0031
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described. In the instance of the preparation of 16.alpha.,17.alpha.-butylidenedioxy-11.beta.,21-dihydroxypregna-1,4-diene- 3,20-dione, a compound having useful therapeutic properties, known also as budesonide, it is possible to obtain the more active epimer with high selectivity and remarkable economic advantages in comparison with the known methods. New 16,17 acetals of pregnane derivatives, which can be prepared by the method of the invention, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.