Process for the production of 2,3-dihydroergolines

US4695635A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerhard Sauer · Berlin, DE
• Gregor Haffer · Berlin, DE

Key dates

• Filing date: Mar 28, 1985
• Grant date: Sep 22, 1987
• Expiry date: Mar 28, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D457/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-bromoergolines can be reduced in good yields, without dimerization as determined by NMR product analysis, to the corresponding 2,3-dihydroergolines under otherwise conventional reducing conditions by introducing 2-bromoergolines, together with sodium borohydride, into trifluoroacetic acid under cooling to prevent the reaction mixture from rising above ambient temperature.