Anti-diabetic pharmaceutical forms and the preparation thereof

US4696815A · kind A · utility

Inventors

• Gottfried Schepky · Biberach, DE
• Rolf-Stefan Brickl
• Eckhard Rupprecht · Dinkelsbühl, DE
• Andreas Greischel · Zell am Harmersbach, DE

Key dates

• Filing date: May 31, 1984
• Grant date: Sep 29, 1987
• Expiry date: May 31, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to novel galenic preparation forms for providing an oral anti-diabetic agent having an improved release of active substance and processes for producing these preparation forms. The novel pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of the metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetic active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. Polyvinyl pyrrolidone is dissolved as carrier in this solution, but the carrier may simultaneously serve as the solubilizing adjuvant. This solution is further processed with other excipients to form corresponding preparation forms.