Novel peptides which are active on the central nervous system and have an action on the cholinergic system

US4696913A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rolf Geiger · Frankfurt am Main, DE
• Hermann Gerhards · Hofheim, DE
• Hansjorg Kruse · Kelkheim, DE

Key dates

• Filing date: Sep 2, 1986
• Grant date: Sep 29, 1987
• Expiry date: Sep 2, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to peptides of the formula I EQU R.sup.4 -A.sup.5 -A.sup.6 -A.sup.7 (I) in which R.sup.4 denotes an acyl group, R.sup.5 denotes D-Lys or Lys, A.sup.6 denotes the radical of phenylalanine, N-methylphenylalanine, 4-alkoxyphenylalanine or 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, and R.sup.7 denotes a basic radical, processes for their preparation and their use.