Thiosulfonate derivatives for inhibiting malformation or destruction of red blood corpuscules
US4696937A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 13, 1985 |
| Grant date | Sep 29, 1987 |
| Priority date | — |
| Expiry date | Nov 13, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel thiosulfonate derivatives of general formu a: EQU R--S--SO.sub.2 --R.sub.1 in which R represents a 1H-imidazol-2-yl, quinolin-2-yl, 5-amino-1,3,4-thiadizol-2-yl or 4,5-dihydro-thiazol-2-yl radical and R.sub.1 represents a lower alkyl, (hydroxy)lower alkyl, phenyl, (lower alkyl) phenyl, (hydroxy lower alkyl) phenyl, (lower alkanoyl) phenyl or quinolin-8-yl radical. The thiosulfonate derivatives in question exert an inhibitory action with respect to the malformation or destruction of red blood corpuscules due to a genetic modification of haemoglobin or to parasites and can, therefore, be used in the treatment of drepanocytosis, malaria and babebiosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.