Medical device for pulsatile transdermal delivery of biologically active agents
US4698062A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 30, 1985 |
| Grant date | Oct 6, 1987 |
| Priority date | — |
| Expiry date | Oct 30, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A medical device and method for the pulsatile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first flux being substantially higher than said second flux; said first and second delivery periods comprising a substantial portion of a predetermined administration period. The device comprises a reservoir of said drug containing an amount of drug sufficient to administer drug at said first and second steady state fluxes during administration period; a reservoir of a skin permeation enhancer for said drug; said reservoir containing an amount of said permeation enhancer sufficient to permit administration of said drug at said first flux only through said first delivery period; and means for maintaining said device on the skin in drug and permeation enhancer transferring relationship thereto a preferred embodiment delivering nitroglycerin and employing ethanol as a permeation enhancer. The device contains means for controlling the maximum delivery rate of one of said drug or enhancer. A preferred embodiment provides for the pulsatile delivery of nitroglycerin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.